Unraveling Tadalafila: What You Need to Know
Guía de Salud Masculina
- 1. basic information
- 2. mechanism of action
- 3. characteristics of drugs
- 4. adverse reactions
- 5. precautions
The question you want to ask may be "tadalafil".
basic information
- Tadalafil is a drug used to treat erectile dysfunction (ED) in men and is a phosphodiesterase type 5 (PDE5) inhibitor.
mechanism of action
- Under normal circumstances, sexual stimulation causes the nerve endings in the corpus cavernosum of the penis to release nitric oxide (NO). NO activates guanylate cyclase and increases cyclic guanosine phosphate (cGMP) levels, which causes the smooth muscles of the corpus cavernosum of the penis to relax and blood flows into the penis to erect.
- While PDE5 breaks down cGMP, tadalafil inhibits the activity of PDE5 and reduces the degradation of cGMP, so that the smooth muscle of the corpus cavernosum can maintain sufficient cGMP concentration under sexual stimulation, thereby maintaining the erection of the penis.
characteristics of drugs
long-term effectiveness: Tadalafil has a long action time, and its effective action time can be as long as about 36 hours, which is different from some other short-acting PDE5 inhibitors.
Not affected by diet: Compared with sildenafil et al., tadalafil is less affected by diet (especially a high-fat diet) when taken.
adverse reactions
- Common adverse reactions include headache, flushing, indigestion, back pain, myalgia, etc. These adverse reactions are mild to moderate and are usually transient.
precautions
- Patients who are taking nitrates such as nitroglycerin are strictly prohibited from using tadalafil because combination of the two may cause severe hypotension.
- Tadalafil should be used under the guidance of a doctor, especially for patients with basic health problems such as cardiovascular disease.